How colonization by microbiota in early life shapes the immune system

Microbial colonization of mucosal tissues during infancy plays an instrumental role in the development and education of the host mammalian immune system. These early-life events can have long-standing consequences: facilitating tolerance to environmental exposures or contributing to the development of disease in later life, including inflammatory bowel disease, allergy, and asthma. Recent studies have begun to define a critical period during early development in which disruption of optimal host-commensal interactions can lead to persistent and in some cases irreversible defects in the development and training of specific immune subsets. Here, we discuss the role of early-life education of the immune system…

• UD
  U.S. Department of Defense

  Award: W81XWH-15-1-0368
• NI
  National Institutes of Health

  Awards: DK44319, R21 AI090102