Resolution of Inflammation: What Controls Its Onset?

An effective resolution program may be able to prevent the progression from non-resolving acute inflammation to persistent chronic inflammation. It has now become evident that coordinated resolution programs initiate shortly after inflammatory responses begin. In this context, several mechanisms provide the fine-tuning of inflammation and create a favorable environment for the resolution phase to take place and for homeostasis to return. In this review, we focus on the events required for an effective transition from the proinflammatory phase to the onset and establishment of resolution. We suggest that several mediators that promote the inflammatory phase of inflammation can simultaneously initiate a program…

• W
  Wellcome

  Award: 086867/Z/08
• WH
  William Harvey Research Foundation
• CD
  Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
• CN
  Conselho Nacional de Desenvolvimento Científico e Tecnológico
• FD
  Fundação de Amparo à Pesquisa do Estado de Minas Gerais
• IN
  Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais
• MR
  Medical Research Council

  Awards: MR/K013068/1, MR/K013068/1
• SF
  Seventh Framework Programme

  Award: FP7-2007-2013