Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity
University Medical Center Groningen · University of Groningen · +22 more institutions
Abstract
Deep sequencing of the gut microbiomes of 1135 participants from a Dutch population-based cohort shows relations between the microbiome and 126 exogenous and intrinsic host factors, including 31 intrinsic factors, 12 diseases, 19 drug groups, 4 smoking categories, and 60 dietary factors. These factors collectively explain 18.7% of the variation seen in the interindividual distance of microbial composition. We could associate 110 factors to 125 species and observed that fecal chromogranin A (CgA), a protein secreted by enteroendocrine cells, was exclusively associated with 61 microbial species whose abundance collectively accounted for 53% of microbial composition. Low CgA concentrations were seen in…
Citation impact
- FWCI
- 88.95
- Percentile
- 100%
- References
- 55
Authors
32- AZAlexandra ZhernakovaCorresponding
University Medical Center Groningen, University of Groningen, TiFN
- AKAlexander KurilshikovCorresponding
Novosibirsk State University, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences
- MJMarc Jan BonderCorresponding
University Medical Center Groningen, University of Groningen
- EFEttje F. TigchelaarCorresponding
University Medical Center Groningen, University of Groningen, TiFN
- MSMelanie Schirmer
Broad Institute, Harvard University
Topics & keywords
- Metagenomics
- Gut microbiome
- Microbiome
- Biology
- Feces
- Gut flora
- Population
- Composition (language)
- Good health and well-being