The biological inorganic chemistry of zinc ions
University of Wrocław · King's College London · +1 more institution
Abstract
The solution and complexation chemistry of zinc ions is the basis for zinc biology. In living organisms, zinc is redox-inert and has only one valence state: Zn(II). Its coordination environment in proteins is limited by oxygen, nitrogen, and sulfur donors from the side chains of a few amino acids. In an estimated 10% of all human proteins, zinc has a catalytic or structural function and remains bound during the lifetime of the protein. However, in other proteins zinc ions bind reversibly with dissociation and association rates commensurate with the requirements in regulation, transport, transfer, sensing, signalling, and storage. In contrast to the extensive knowledge about zinc proteins, the coordination…
Citation impact
- FWCI
- 37.33
- Percentile
- 100%
- References
- 155
Authors
2Topics & keywords
- Zinc
- Chemistry
- Coordination complex
- Valence (chemistry)
- Bioinorganic chemistry
- Inorganic chemistry
- Biochemistry
- Organic chemistry