Targeted Drug Delivery with Polymers and Magnetic Nanoparticles: Covalent and Noncovalent Approaches, Release Control, and Clinical Studies
Czech Academy of Sciences, Institute of Macromolecular Chemistry · Regional Centre of Advanced Technologies and Materials · +1 more institution
Abstract
Targeted delivery combined with controlled drug release has a pivotal role in the future of personalized medicine. This review covers the principles, advantages, and drawbacks of passive and active targeting based on various polymer and magnetic iron oxide nanoparticle carriers with drug attached by both covalent and noncovalent pathways. Attention is devoted to the tailored conjugation of targeting ligands (e.g., enzymes, antibodies, peptides) to drug carrier systems. Similarly, the approaches toward controlled drug release are discussed. Various polymer-drug conjugates based, for example, on polyethylene glycol (PEG), N-(2-hydroxypropyl)methacrylamide (HPMA), polymeric micelles, and nanoparticle carriers are…
Citation impact
- FWCI
- 103.68
- Percentile
- 100%
- References
- 799
Authors
6- KUKarel UlbrichCorresponding
Czech Academy of Sciences, Institute of Macromolecular Chemistry
- KHKateřina Holá
Regional Centre of Advanced Technologies and Materials, Palacký University Olomouc
- VŠVladimír Šubr
Czech Academy of Sciences, Institute of Macromolecular Chemistry
- ABAristides Bakandritsos
Regional Centre of Advanced Technologies and Materials, Palacký University Olomouc
- JTJiří Tuček
Regional Centre of Advanced Technologies and Materials, Palacký University Olomouc
Topics & keywords
- Chemistry
- Covalent bond
- Drug delivery
- Non-covalent interactions
- Nanoparticle
- Polyethylene glycol
- Combinatorial chemistry
- Targeted drug delivery
- Good health and well-being