The migraine generator revisited: continuous scanning of the migraine cycle over 30 days and three spontaneous attacks
Universität Hamburg · University Medical Center Hamburg-Eppendorf
Abstract
Functional imaging using positron emission tomography and later functional magnetic resonance imaging revealed a particular brainstem area that is believed to be specifically activated in migraine during, but not outside of the attack, and consequently has been coined the ‘migraine generator’ . However, the pathophysiological concept behind this term is not undisputed and typical migraine premonitory symptoms such as fatigue and yawning, but also a typical association of attacks to circadian and menstrual cycles, all make the hypothalamus a possible regulating region of migraine attacks. Neuroimaging studies investigating native human migraine attacks however are scarce and for methodological but also clinical…
Citation impact
- FWCI
- 39.63
- Percentile
- 100%
- References
- 22
Authors
2Topics & keywords
- Migraine
- Brainstem
- Neuroscience
- Functional magnetic resonance imaging
- Medicine
- Pons
- Neuroimaging
- Cortical spreading depression
- Good health and well-being