The role of ER stress in lipid metabolism and lipotoxicity

The endoplasmic reticulum (ER) is a cellular organelle important for regulating calcium homeostasis, lipid metabolism, protein synthesis, and posttranslational modification and trafficking. Numerous environmental, physiological, and pathological insults disturb ER homeostasis, referred to as ER stress, in which a collection of conserved intracellular signaling pathways, termed the unfolded protein response (UPR), are activated to maintain ER function for cell survival. However, excessive and/or prolonged UPR activation leads to initiation of self-destruction through apoptosis. Excessive accumulation of lipids and their intermediate products causes metabolic abnormalities and cell death, called lipotoxicity, in…

• NR
  National Research Foundation of Korea

  Award: NRF-2015R1D1A1A01058846
• OO
  Office of Extramural Research, National Institutes of Health

  Awards: DK103183, CA128814, DK042394, DK088227