RAD51B in Familial Breast Cancer
University of Helsinki · Helsinki University Hospital · +75 more institutions
Indexed incrossrefdatacitedoajpubmed
Abstract
Common variation on 14q24.1, close to RAD51B, has been associated with breast cancer: rs999737 and rs2588809 with the risk of female breast cancer and rs1314913 with the risk of male breast cancer. The aim of this study was to investigate the role of RAD51B variants in breast cancer predisposition, particularly in the context of familial breast cancer in Finland. We sequenced the coding region of RAD51B in 168 Finnish breast cancer patients from the Helsinki region for identification of possible recurrent founder mutations. In addition, we studied the known rs999737, rs2588809, and rs1314913 SNPs and RAD51B haplotypes in 44,791 breast cancer cases and 43,583 controls from 40 studies participating in the Breast…
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Authors
98- LMLiisa M. Pelttari
University of Helsinki, Helsinki University Hospital
- SKSofia Khan
University of Helsinki, Helsinki University Hospital
- MVMikko Vuorela
University of Oulu
- JIJohanna I. Kiiski
University of Helsinki, Helsinki University Hospital
- SVSara Vilske
University of Helsinki, Helsinki University Hospital
Topics & keywords
Topics
Keywords
- Breast cancer
- Odds ratio
- Single-nucleotide polymorphism
- Medicine
- Oncology
- Male breast cancer
- Haplotype
- Cancer
UN Sustainable Development Goals
- Good health and well-being
No related works found for this paper.
Funding
- BCBreast Cancer Research FoundationAwards: 108419, 106332, CA63464, R01CA100374, 39346, CA116201, CA128978, 209057, 01KH0402, 108253, CA098758, PSR-SIIRI-701, CA132839, 70-2892-BR I, CRN-87521, 193387/V50, 193387/H10, CA54281
- DKDeutsches KrebsforschungszentrumAwards: 106332, CRN-87521, CA63464, 01KH0402, 193387/H10, 193387/V50, CA116201, CA098758, CA132839, 70-2892-BR I, 108253, R01CA100374, 209057, CA54281, 108419, CA128978, PSR-SIIRI-701, 39346
- KKreftforeningenAwards: CRN-87521, R01CA100374, CA63464, CA54281, CA128978, CA132839, 193387/V50, 39346, 106332, 70-2892-BR I, 209057, PSR-SIIRI-701, 193387/H10, 108419, 108253, CA116201, CA098758, 01KH0402
- AKAlfred Kordelinin Säätiö
- DFDavid F. and Margaret T. Grohne Family FoundationAwards: 106332, CA63464, 70-2892-BR I, 01KH0402, CA116201, 108253, CA128978, CA132839, R01CA100374, 209057, 193387/V50, CA098758, CA54281, PSR-SIIRI-701, 193387/H10, 39346, 108419, CRN-87521
- FDFondation du cancer du sein du QuébecAwards: 193387/H10, 193387/V50, 108419, CA098758, CRN-87521, PSR-SIIRI-701, 70-2892-BR I, R01CA100374, 209057, CA128978, 108253, CA116201, 01KH0402, 106332, CA54281, CA132839, CA63464, 39346
- CRCancer Research UKAwards: CA132839, 106332, CA098758, CA54281, CA63464, 108253, 209057, C1287, C1287/A12014, 193387/V50, CRN-87521, 70-2892-BR I, CA116201, CA128978, R01CA100374, 39346, 108419, 01KH0402, 193387/H10, PSR-SIIRI-701
- CICancer Institute NSWAwards: 01KH0402, 108253, CA098758, CA54281, 39346, R01CA100374, 209057, 70-2892-BR I, CA63464, PSR-SIIRI-701, 193387/H10, CA128978, 106332, 108419, 193387/V50, CA116201, CRN-87521, CA132839
- BFBundesministerium für Bildung und ForschungAwards: CA128978, 193387/V50, 70-2892-BR I, 39346, CA54281, CA132839, 01KH0402, 108419, PSR-SIIRI-701, CA098758, CA116201, 106332, 193387/H10, CA63464, 108253, 209057, R01CA100374, CRN-87521
- SKSuomen Kulttuurirahasto
- FWFonds Wetenschappelijk OnderzoekAwards: CA132839, 193387/H10, 209057, CA116201, CRN-87521, 108253, R01CA100374, PSR-SIIRI-701, 193387/V50, 01KH0402, 106332, 70-2892-BR I, 39346, CA54281, CA128978, 108419, CA098758, CA63464
- MDMinisterio de Economía y CompetitividadAwards: PSR-SIIRI-701, 193387/H10, CA116201, 39346, 193387/V50, 70-2892-BR I, CA63464, 106332, 108253, CA54281, CRN-87521, 108419, R01CA100374, CA098758, CA132839, CA128978, 01KH0402, 209057
- BHBiomedicum Helsinki-säätiö
- AIAssociazione Italiana per la Ricerca sul CancroAwards: 108253, CA63464, 193387/H10, 108419, 193387/V50, CA116201, 106332, 209057, 01KH0402, R01CA100374, CA098758, 39346, CRN-87521, CA132839, CA54281, CA128978, PSR-SIIRI-701, 70-2892-BR I
- NFNorges ForskningsrådAwards: 209057, CA54281, 193387/H10, R01CA100374, 108419, CRN-87521, 106332, CA116201, 108253, 01KH0402, PSR-SIIRI-701, CA132839, 39346, CA128978, 193387/V50, CA098758, CA63464, 70-2892-BR I
- DKDeutsche KrebshilfeAwards: CA63464, 193387/H10, CA132839, CA128978, PSR-SIIRI-701, 106332, 108253, 70-2892-BR I, 106332, 108253, 108419, CA098758, 209057, 108419, 01KH0402, CRN-87521, 39346, CA116201, 193387/V50, CA54281, 70-2892-BR I, R01CA100374
- OTOrionin Tutkimussäätiö
- MDMinistero dello Sviluppo Economico
- NINational Institutes of HealthAwards: CA132839, 108253, CA116167, R01CA100374, 39346, CA098758, 193387/V50, CA116201, 70-2892-BR I, 193387/H10, PSR-SIIRI-701, CA54281, CA176785, 01KH0402, 106332, CA63464, 108419, 209057, CRN-87521, CA128978
- UAU.S. ArmyAward: DAMD17-01-1-0729
- CICanadian Institutes of Health ResearchAwards: 106332, CA63464, 209057, 193387/V50, CA128978, R01CA100374, PSR-SIIRI-701, 108253, 70-2892-BR I, 01KH0402, 39346, 108419, CA116201, CA132839, 193387/H10, CA54281, CRN-87521, CA098758
- MRMedical Research CouncilAwards: CRN-87521, CA128978, CA116201, R01CA100374, 01KH0402, 193387/V50, 106332, CA63464, 193387/H10, 108419, 70-2892-BR I, 108253, CA54281, CA098758, CA132839, 39346, 209057, PSR-SIIRI-701
- NHNational Health and Medical Research CouncilAwards: 251553, 199600, 400281, 209057, 251553 and 504711, 209057, 400413, 400281, 400413, 504711
- CCCancer Council South Australia
- CCCancer Council VictoriaAwards: CA132839, 106332, PSR-SIIRI-701, 39346, 209057, 108419, 108253, CA098758, CA54281, CA116201, 193387/V50, 01KH0402, R01CA100374, 70-2892-BR I, CRN-87521, CA63464, 193387/H10, CA128978
- CCCancer Council NSW
- CCCancer Council Tasmania
- MRMedical Research and Materiel CommandAward: DAMD17-01-1-0729