articleBioinformaticsSep 22, 2016HYBRID OA

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

JZJie ZhengAMA. Mesut ErzurumluogluBEBenjamin ElsworthJPJohn P. KempLJLaurence J Howe

University of Bristol · University of Leicester · +5 more institutions

PubMed
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Abstract

MOTIVATION: LD score regression is a reliable and efficient method of using genome-wide association study (GWAS) summary-level results data to estimate the SNP heritability of complex traits and diseases, partition this heritability into functional categories, and estimate the genetic correlation between different phenotypes. Because the method relies on summary level results data, LD score regression is computationally tractable even for very large sample sizes. However, publicly available GWAS summary-level data are typically stored in different databases and have different formats, making it difficult to apply LD score regression to estimate genetic correlations across many different traits simultaneously.…

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Topics & keywords

Topics
Keywords
  • Heritability
  • Genome-wide association study
  • SNP
  • Interface (matter)
  • Statistics
  • Genetic correlation
  • Correlation
  • Computer science
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