Undirected, Homogeneous C–H Bond Functionalization: Challenges and Opportunities

The functionalization of C-H bonds has created new approaches to preparing organic molecules by enabling new strategic "disconnections" during the planning of a synthetic route. Such functionalizations also have created the ability to derivatize complex molecules by modifying one or more of the many C-H bonds. For these reasons, researchers are developing new types of functionalization reactions of C-H bonds and new applications of these processes. These C-H bond functionalization reactions can be divided into two general classes: those directed by coordination to an existing functional group prior to the cleavage of the C-H bond (directed) and those occurring without coordination prior to cleavage of the C-H…

• C
  Chevron
• AC
  American Chemical Society
• NI
  National Institute of General Medical Sciences

  Awards: GM-55382, GM-115812
• DO
  Division of Chemistry

  Award: CHE-01213409