Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group

Group, for the ENIGMA-Major Depressive Disorder Working; Schmaal, Lianne; Hibar, Derrek P.; Sämann, Philipp G.; Hall, Geoffrey B.; Baune, Bernhard T.; Jahanshad, Neda; Cheung, J.; Erp, Theo G.M. van; Bos, Daniël; Ikram, M. Arfan; Vernooij, Meike W.; Niessen, Wiro J.; Tiemeier, Henning; Hofman, Albert; Wittfeld, Katharina; Grabe, Hans J.; Janowitz, Deborah; Bülow, Robin; Selonke, M; Völzke, Henry; Grotegerd, Dominik; Dannlowski, Udo; Arolt, Volker; Opel, Nils; Heindel, Walter; Kugel, Harald; Hoehn, David; Czisch, Michael; Couvy‐Duchesne, Baptiste; Rentería, Miguel E.; Strike, Lachlan T.; Wright, Margaret J.; Mills, Natalie; Zubicaray, Greig I. de; McMahon, Katie L.; Medland, Sarah E.; Martin, Nicholas G.; Gillespie, Nathan A.; Goya‐Maldonado, Roberto; Gruber, Oliver; Krämer, Bernd; Hatton, Sean N.; Lagopoulos, Jim; Hickie, Ian B.; Frodl, Thomas; Carballedo, Angela; Frey, Eva-Maria; Velzen, Laura S. van; Penninx, Brenda W.J.H.; Tol, M-J van; Wee, Nic J. van der; Davey, Christopher G.; Harrison, Ben J.; Mwangi, Benson; Cao, Bo; Soares, Jair C.; Veer, Ilya M.; Walter, Henrik; Schoepf, Dieter; Zurowski, Bartosz; Konrad, Carsten; Schramm, Elisabeth; Normann, Claus; Schnell, Knut; Sacchet, Matthew D.; Gotlib, Ian H.; MacQueen, Glenda; Godlewska, Beata R.; Nickson, Thomas E.; McIntosh, Andrew M.; Papmeyer, Martina; Whalley, Heather C.; Hall, Jérémy; Sussmann, J. E.; Li, Mingzhe; Walter, Martin; Aftanas, Lyubomir I.; Brack, Ivan; Бохан, Н. А.; Thompson, Paul M.; Veltman, Dick J.

doi:10.1038/mp.2016.60

reviewMolecular PsychiatryMay 3, 2016HYBRID OA

Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group

FTfor the ENIGMA-Major Depressive Disorder Working GroupLSLianne Schmaal DPDerrek P. Hibar PGPhilipp G. Sämann GBGeoffrey B. Hall

Amsterdam Neuroscience · Imaging Center · +50 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

The neuro-anatomical substrates of major depressive disorder (MDD) are still not well understood, despite many neuroimaging studies over the past few decades. Here we present the largest ever worldwide study by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Major Depressive Disorder Working Group on cortical structural alterations in MDD. Structural T1-weighted brain magnetic resonance imaging (MRI) scans from 2148 MDD patients and 7957 healthy controls were analysed with harmonized protocols at 20 sites around the world. To detect consistent effects of MDD and its modulators on cortical thickness and surface area estimates derived from MRI, statistical effects from sites were…

Citation impact

1,329

total citations

FWCI: 44.90
Percentile: 100%
References: 59

Citations per year

Authors

82

FT
for the ENIGMA-Major Depressive Disorder Working GroupCorresponding
Amsterdam Neuroscience
LS
Lianne Schmaal
Amsterdam Neuroscience, Imaging Center
DP
Derrek P. Hibar
Max Planck Institute of Psychiatry, Imaging Center
PG
Philipp G. Sämann
Max Planck Institute of Psychiatry, McMaster University
GB
Geoffrey B. Hall
The University of Adelaide, McMaster University

Topics & keywords

Topics

Keywords

Depression (economics)
Psychology
Major depressive disorder
Clinical psychology
Psychiatry
Neuroscience
Medicine
Cognition

No related works found for this paper.