Causal evidence for the role of REM sleep theta rhythm in contextual memory consolidation

Rapid eye movement sleep (REMS) has been linked with spatial and emotional memory consolidation. However, establishing direct causality between neural activity during REMS and memory consolidation has proven difficult because of the transient nature of REMS and significant caveats associated with REMS deprivation techniques. In mice, we optogenetically silenced medial septum γ-aminobutyric acid-releasing (MS(GABA)) neurons, allowing for temporally precise attenuation of the memory-associated theta rhythm during REMS without disturbing sleeping behavior. REMS-specific optogenetic silencing of MS(GABA) neurons selectively during a REMS critical window after learning erased subsequent novel object place…

• HF
  Human Frontier Science Program

  Award: RGY0076/2012
• DF
  Douglas Foundation
• MU
  McGill University
• UO
  University of Bern
• CF
  Canada Foundation for Innovation
• SN
  Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
• CR
  Canada Research Chairs
• CI
  Canadian Institutes of Health Research
• NS
  Natural Sciences and Engineering Research Council of Canada
• FD
  Fonds de Recherche du Québec - Santé