Invasive Vulvar Paget's Disease

S Disease (VPD).Vulvar Paget's Disease (VPD) is an intraepithelial adenocarcinoma, with or without underlying invasive adenocarcinoma.It can be primary (cutaneous and/or adnexal) or secondary, originating from the recto-colic or urothelial epithelium.First described by Dubreuilh in 1901, VPD is not always a purely intraepithelial proliferation; it may present as an invasive form.The reported frequency of invasion varies between 10% and 47%, based on small case series.Three levels of invasion have been described: (1) in situ within the epidermis, (2) microinvasion of the papillary dermis, and (3) deep invasion into the reticular dermis and hypodermis.VPD is a rare cutaneous malignancy, predominantly observed in…