Nanoparticle-mediated brain drug delivery: Overcoming blood–brain barrier to treat neurodegenerative diseases
University of Beira Interior · Biocant · +3 more institutions
Abstract
The blood-brain barrier (BBB) is a vital boundary between neural tissue and circulating blood. The BBB's unique and protective features control brain homeostasis as well as ion and molecule movement. Failure in maintaining any of these components results in the breakdown of this specialized multicellular structure and consequently promotes neuroinflammation and neurodegeneration. In several high incidence pathologies such as stroke, Alzheimer's (AD) and Parkinson's disease (PD) the BBB is impaired. However, even a damaged and more permeable BBB can pose serious challenges to drug delivery into the brain. The use of nanoparticle (NP) formulations able to encapsulate molecules with therapeutic value, while…
Citation impact
- FWCI
- 70.34
- Percentile
- 100%
- References
- 169
Authors
6- CSCláudia Saraiva
University of Beira Interior
- CPCatarina Praça
Biocant, Centro de Neurociências e Biologia Celular, Université d'Artois, University of Coimbra
- RFRaquel Ferreira
University of Beira Interior
- TSTiago Santos
University of Beira Interior
- LFLino FerreiraCorresponding
Biocant, Centro de Neurociências e Biologia Celular, University of Coimbra
Topics & keywords
- Blood–brain barrier
- Neuroinflammation
- Drug delivery
- Drug delivery to the brain
- Neuroscience
- Neurodegeneration
- Medicine
- Drug
- Good health and well-being