reviewChemical ReviewsMay 17, 2016GREEN OA

Water Determines the Structure and Dynamics of Proteins

MBMarie‐Claire Bellissent‐FunelAHAli HassanaliMHMartina HavenithRHRichard H. HenchmanPPPeter Pohl

CEA Paris-Saclay · Commissariat à l'Énergie Atomique et aux Énergies Alternatives · +12 more institutions

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Abstract

Water is an essential participant in the stability, structure, dynamics, and function of proteins and other biomolecules. Thermodynamically, changes in the aqueous environment affect the stability of biomolecules. Structurally, water participates chemically in the catalytic function of proteins and nucleic acids and physically in the collapse of the protein chain during folding through hydrophobic collapse and mediates binding through the hydrogen bond in complex formation. Water is a partner that slaves the dynamics of proteins, and water interaction with proteins affect their dynamics. Here we provide a review of the experimental and computational advances over the past decade in understanding the role of…

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Topics & keywords

Topics
Keywords
  • Chemistry
  • Biomolecule
  • Molecular dynamics
  • Protein dynamics
  • Chemical physics
  • Neutron spectroscopy
  • Folding (DSP implementation)
  • Hydrogen bond
UN Sustainable Development Goals
  • Clean water and sanitation
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