Validation of a Prediction Tool for Chemotherapy Toxicity in Older Adults With Cancer
Thomas Jefferson University · Duke University · +7 more institutions
Abstract
PURPOSE: Older adults are at increased risk for chemotherapy toxicity, and standard oncology assessment measures cannot identify those at risk. A predictive model for chemotherapy toxicity was developed (N = 500) that consisted of geriatric assessment questions and other clinical variables. This study aims to externally validate this model in an independent cohort (N = 250). PATIENTS AND METHODS: Patients age ≥ 65 years with a solid tumor, fluent in English, and who were scheduled to receive a new chemotherapy regimen were recruited from eight institutions. Risk of chemotherapy toxicity was calculated (low, medium, or high risk) on the basis of the prediction model before the start of chemotherapy.…
Citation impact
- FWCI
- 38.36
- Percentile
- 100%
- References
- 28
Authors
17- AHArti HurriaCorresponding
Thomas Jefferson University, Duke University, SUNY Upstate Medical University, University of Rochester Medical Center, Sidney Kimmel Cancer Center
- SGSupriya G. Mohile
Thomas Jefferson University, SUNY Upstate Medical University, University of Rochester Medical Center, Sidney Kimmel Cancer Center
- AGAjeet Gajra
SUNY Upstate Medical University, University of Rochester Medical Center
- HDHeidi D. Klepin
SUNY Upstate Medical University, University of Rochester Medical Center
- HBHyman B. Muss
SUNY Upstate Medical University, University of Rochester Medical Center
Topics & keywords
- Medicine
- Toxicity
- Chemotherapy
- Receiver operating characteristic
- Area under the curve
- Internal medicine
- Cohort
- Regimen
- Good health and well-being