reviewCell Death and DiseaseMay 19, 2016GOLD OA

Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer

QQQian QuFZFanning ZengXLXiaonan LiuQJQiming J. WangFDFeihong Deng

Southern Medical University · University of Pittsburgh

PubMed
Indexed incrossrefdoajpubmed

Abstract

Tumor cells exhibit unique metabolic adaptations that are increasingly viewed as potential targets for novel and specific cancer therapies. Among these targets, the carnitine palmitoyltransferase system is responsible for delivering the long-chain fatty acid (FA) from cytoplasm into mitochondria for oxidation, where carnitine palmitoyltransferase I (CPTI) catalyzes the rate-limiting step of fatty acid oxidation (FAO). With increasing understanding of the crucial role had by fatty acid oxidation in cancer, CPTI has received renewed attention as a pivotal mediator in cancer metabolic mechanism. CPTI activates FAO and fuels cancer growth via ATP and NADPH production, constituting an essential part of cancer…

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564
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FWCI
10.76
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100%
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99
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Authors

5

Topics & keywords

Topics
Keywords
  • Carnitine
  • Carnitine O-palmitoyltransferase
  • Beta oxidation
  • Carnitine palmitoyltransferase I
  • Cancer cell
  • Fatty acid
  • Mediator
  • Fatty acid metabolism
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