Self-Targeting Fluorescent Carbon Dots for Diagnosis of Brain Cancer Cells
Changchun Institute of Applied Chemistry · State Key Laboratory of Polymer Physics and Chemistry · +6 more institutions
Abstract
A new type of carbon dots (CD-Asp) with targeting function toward brain cancer glioma was synthesized via a straightforward pyrolysis route by using D-glucose and L-aspartic acid as starting materials. The as-prepared CD-Asp exhibits not only excellent biocompatibility and tunable full-color emission, but also significant capability of targeting C6 glioma cells without the aid of any extra targeting molecules. In vivo fluorescence images showed high-contrast biodistribution of CD-Asp 15 min after tail vein injection. A much stronger fluorescent signal was detected in the glioma site than that in normal brain, indicating their ability to freely penetrate the blood-brain barrier and precisely targeting glioma…
Citation impact
- FWCI
- 18.39
- Percentile
- 100%
- References
- 57
Authors
10- MZMin ZhengCorresponding
Changchun Institute of Applied Chemistry, State Key Laboratory of Polymer Physics and Chemistry, Changchun University of Technology, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences
- SRShaobo Ruan
Sichuan University
- SLShi Liu
Chinese Academy of Sciences, State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry
- TSTingting Sun
University of Chinese Academy of Sciences, Chinese Academy of Sciences, State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry
- DQDan Qu
Chinese Academy of Sciences, Changchun Institute of Optics, Fine Mechanics and Physics, University of Chinese Academy of Sciences
Topics & keywords
- Fluorescence
- Nanotechnology
- Quantum dot
- Materials science
- Carbon fibers
- Brain cancer
- Cancer
- Cancer cell