Role of epithelial to mesenchymal transition in hepatocellular carcinoma
University of Bari Aldo Moro · Comprehensive Cancer Center Vienna · +1 more institution
Abstract
The epithelial to mesenchymal transition (EMT) is a multistep biological process whereby epithelial cells change in plasticity by transient de-differentiation into a mesenchymal phenotype. EMT and its reversal, mesenchymal to epithelial transition (MET), essentially occur during embryogenetic morphogenesis and have been increasingly described in fibrosis and cancer during the last decade. In carcinoma progression, EMT plays a crucial role in early steps of metastasis when cells lose cell-cell contacts due to ablation of E-cadherin and acquire increased motility to spread into surrounding or distant tissues. Epithelial plasticity has become a hot issue in hepatocellular carcinoma (HCC), as strong inducers of…
Citation impact
- FWCI
- 21.07
- Percentile
- 100%
- References
- 122
Authors
4Topics & keywords
- Epithelial–mesenchymal transition
- Cancer research
- Metastasis
- Hepatocellular carcinoma
- Carcinogenesis
- Biology
- Transdifferentiation
- Mesenchymal stem cell
- Good health and well-being