The hnRNP family: insights into their role in health and disease
University of Antwerp · VIB-UAntwerp Center for Molecular Neurology
Indexed incrossrefpubmed
Abstract
Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism including alternative splicing, mRNA stabilization, and transcriptional and translational regulation. Many hnRNPs share general features, but differ in domain composition and functional properties. This review will discuss the current knowledge about the different hnRNP family members, focusing on their structural and functional divergence. Additionally, we will highlight their involvement in neurodegenerative diseases and cancer, and the potential to develop RNA-based therapies.
Citation impact
1,139
total citations
- FWCI
- 33.25
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- 100%
- References
- 136
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Authors
3Topics & keywords
Topics
Keywords
- Biology
- RNA splicing
- Heterogeneous ribonucleoprotein particle
- Heterogeneous nuclear ribonucleoprotein
- RNA-binding protein
- Computational biology
- Human genetics
- Ribonucleoprotein
UN Sustainable Development Goals
- Good health and well-being
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