Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade

SUMMARY The Cancer Genome Atlas revealed the genomic landscapes of common human cancers. In parallel, immunotherapy with checkpoint blockers is transforming the treatment of advanced cancers. As only a minority of the patients is responsive to checkpoint blockers, the identification of predictive markers and the mechanisms of resistance is a subject of intense research. To facilitate understanding of the tumor-immune cell interactions, we characterized the intratumoral immune landscapes and the cancer antigenomes from 20 solid cancers, and created The Cancer Immunome Atlas ( http://tcia.at ). Cellular characterization of the immune infiltrates revealed a role of cancer-germline antigens in spontaneous immunity…

• EC
  European Commission
• AS
  Austrian Science Fund
• ON
  Oesterreichische Nationalbank

  Award: 16534