The Role of Micelle Size in Tumor Accumulation, Penetration, and Treatment
Zhejiang University · State Key Laboratory of Chemical Engineering · +2 more institutions
Abstract
The specific sizes that determine optimal nanoparticle tumor accumulation, penetration, and treatment remain inconclusive because many studies compared nanoparticles with multiple physicochemical variables (e.g., chemical structures, shapes, and other physical properties) in addition to the size. In this study, we synthesized amphiphilic block copolymers of 7-ethyl-10-hydroxylcamptothecin (SN38) prodrug and fabricated micelles with sizes ranging from 20 to 300 nm from a single copolymer. The as-prepared micelles had exactly the same chemical structures and similar physical properties except for size, which provided an ideal platform for a systematic investigation of the size effects in cancer drug delivery. We…
Citation impact
- FWCI
- 27.41
- Percentile
- 100%
- References
- 36
Authors
9- JWJinqiang WangCorresponding
Zhejiang University, State Key Laboratory of Chemical Engineering
- WMWeiwei Mao
Zhejiang University, State Key Laboratory of Chemical Engineering
- LLLye Lin Lock
Johns Hopkins University
- JTJianbin Tang
State Key Laboratory of Chemical Engineering, Zhejiang University
- MSMeihua Sui
Zhejiang University, State Key Laboratory of Chemical Engineering
Topics & keywords
- Micelle
- Penetration (warfare)
- Nanoparticle
- Materials science
- Copolymer
- Prodrug
- Drug delivery
- Amphiphile
- No poverty