ROS homeostasis and metabolism: a dangerous liason in cancer cells
University of Turin · VIB-KU Leuven Center for Microbiology · +1 more institution
Abstract
Tumor cells harbor genetic alterations that promote a continuous and elevated production of reactive oxygen species. Whereas such oxidative stress conditions would be harmful to normal cells, they facilitate tumor growth in multiple ways by causing DNA damage and genomic instability, and ultimately, by reprogramming cancer cell metabolism. This review outlines the metabolic-dependent mechanisms that tumors engage in when faced with oxidative stress conditions that are critical for cancer progression by producing redox cofactors. In particular, we describe how the mitochondria has a key role in regulating the interplay between redox homeostasis and metabolism within tumor cells. Last, we will discuss the…
Citation impact
- FWCI
- 59.53
- Percentile
- 100%
- References
- 171
Authors
2Topics & keywords
- Oxidative stress
- Cancer cell
- Homeostasis
- Reactive oxygen species
- Reprogramming
- Mitochondrion
- Cell biology
- Biology
- Life in Land