reviewScienceJun 2, 2016Closed access

Epigenetic balance of gene expression by Polycomb and COMPASS families

APAndrea PiuntiASAli Shilatifard

Northwestern University

PubMed
Indexed incrossrefpubmed

Abstract

Epigenetic regulation of gene expression in metazoans is central for establishing cellular diversity, and its deregulation can result in pathological conditions. Although transcription factors are essential for implementing gene expression programs, they do not function in isolation and require the recruitment of various chromatin-modifying and -remodeling machineries. A classic example of developmental chromatin regulation is the balanced activities of the Polycomb group (PcG) proteins within the PRC1 and PRC2 complexes, and the Trithorax group (TrxG) proteins within the COMPASS family, which are highly mutated in a large number of human diseases. In this review, we will discuss the latest findings regarding…

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Authors

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Topics & keywords

Topics
Keywords
  • Epigenetics
  • Chromatin
  • Compass
  • Biology
  • Polycomb-group proteins
  • Genetics
  • Chromatin remodeling
  • Regulation of gene expression
UN Sustainable Development Goals
  • Good health and well-being
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