TFEB at a glance
Telethon Institute Of Genetics And Medicine · Baylor College of Medicine · +3 more institutions
Abstract
The transcription factor EB (TFEB) plays a pivotal role in the regulation of basic cellular processes, such as lysosomal biogenesis and autophagy. The subcellular localization and activity of TFEB are regulated by mechanistic target of rapamycin (mTOR)-mediated phosphorylation, which occurs at the lysosomal surface. Phosphorylated TFEB is retained in the cytoplasm, whereas dephosphorylated TFEB translocates to the nucleus to induce the transcription of target genes. Thus, a lysosome-to-nucleus signaling pathway regulates cellular energy metabolism through TFEB. Recently, in vivo studies have revealed that TFEB is also involved in physiological processes, such as lipid catabolism. TFEB has attracted a lot of…
Citation impact
- FWCI
- 37.44
- Percentile
- 100%
- References
- 93
Authors
2Topics & keywords
- TFEB
- Autophagy
- Biology
- Basic helix-loop-helix leucine zipper transcription factors
- Cell biology
- Lysosome
- Transcription factor
- Mechanistic target of rapamycin
- Affordable and clean energy