articleInternational Journal of Biological SciencesJan 1, 2016GOLD OA

Exosomes Secreted by Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Repair Critical-Sized Bone Defects through Enhanced Angiogenesis and Osteogenesis in Osteoporotic Rats

XQXin QiJZJieyuan ZhangHYHong YuanZXZhengliang XuQLQing Li

Shanghai Sixth People's Hospital · Shanghai Jiao Tong University

PubMed
Indexed incrossrefdoajpubmed

Abstract

Bone defects caused by trauma, severe infection, tumor resection and skeletal abnormalities are common osteoporotic conditions and major challenges in orthopedic surgery, and there is still no effective solution to this problem. Consequently, new treatments are needed to develop regeneration procedures without side effects. Exosomes secreted by mesenchymal stem cells (MSCs) derived from human induced pluripotent stem cells (hiPSCs, hiPSC-MSC-Exos) incorporate the advantages of both MSCs and iPSCs with no immunogenicity. However, there are no reports on the application of hiPSC-MSC-Exos to enhance angiogenesis and osteogenesis under osteoporotic conditions. HiPSC-MSC-Exos were isolated and identified before…

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535
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9

Topics & keywords

Topics
Keywords
  • Mesenchymal stem cell
  • Angiogenesis
  • Cell biology
  • Induced pluripotent stem cell
  • Microvesicles
  • Exosome
  • Bioluminescence imaging
  • Chemistry
UN Sustainable Development Goals
  • Good health and well-being
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