DNA methylation-based measures of biological age: meta-analysis predicting time to death
National Institutes of Health · National Heart Lung and Blood Institute · +35 more institutions
Indexed incrossrefpubmed
Abstract
). Overall, this study a) strengthens the evidence that epigenetic age predicts all-cause mortality above and beyond chronological age and traditional risk factors, and b) demonstrates that epigenetic age estimates that incorporate information on blood cell counts lead to highly significant associations with all-cause mortality.
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1,209
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Authors
66- BHBrian H. ChenCorresponding
National Institutes of Health, National Heart Lung and Blood Institute, Framingham Heart Study, National Institute on Aging
- RERiccardo E. Marioni
The University of Queensland, Institute of Genetics and Cancer, University of Edinburgh
- ECElena Colicino
Columbia University
- MJMarjolein J. Peters
- CWCavin Ward‐Caviness
Helmholtz Zentrum München
Topics & keywords
Topics
Keywords
- Epigenetics
- dNaM
- DNA methylation
- Demography
- Biological age
- Biology
- Ethnic group
- Medicine
UN Sustainable Development Goals
- Good health and well-being
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Funding
- UDU.S. Department of Health and Human ServicesAwards: HHSN268201100002C, 5RC2HL102419, HHSN268201100046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C, and HHSN271201100004C, HHSN268201100003C, HHSN268201100001C, HHSN268201500001I, HHSN271201100004C, HHSN268201100046C, HHSN268201100004C
- UDU.S. Department of Veterans Affairs
- BABrigham and Women's Hospital
- OSOhio State University
- WFWake Forest University
- UOUniversity of Pittsburgh
- WTWellcome TrustAward: FP7/2007-2013
- SGScottish Government
- NINational Institute for Health and Care ResearchAward: FP7/2007-2013
- AUAge UKAward: MR/K026992/1
- KCKing's College London
- ECEuropean CommissionAwards: FP7/2007-2013, 250157, 2007-2013, FP7/2007, 305280
- UOUniversity of EdinburghAward: MR/K026992/1
- GFGerman-Israeli Foundation for Scientific Research and Development
- UOUniversity of Queensland
- ZZonMw
- BFBundesministerium für Bildung und Forschung
- EMErasmus Medisch CentrumAward: 014-93-015
- BFBundesministerium für Gesundheit
- NONederlandse Organisatie voor Wetenschappelijk OnderzoekAwards: 911-03-012, 175.010.2005.011, FP7/2007-2013, 917103521
- CFCentre for Cognitive Ageing and Cognitive EpidemiologyAward: MR/K026992/1
- NINational Institutes of HealthAwards: HHSN268201100012C, 5RC2HL102419, FP7/2007-2013, HHSN268201100008C, HHSN268201100006C, HHSN268201100004C, HHSN268201100007C, HHSN268201100046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C, and HHSN271201100004C, HHSN268201100046C, HHSN271201100004C, HHSN268201100011C, HHSN268201100001C, HHSN268201100010C, HHSN268201100002C, 1U34AG051425-01, HHSN268201100009C, HHSN268201100005C, N01-HC-25195, HHSN268201100003C, HHSN268201500001I
- DFDirectorate for Biological Sciences
- UAUniversity at Buffalo
- MRMedical Research CouncilAwards: MR/K026992/1, MR/K026992/1, MR/M013111/1
- BABiotechnology and Biological Sciences Research CouncilAward: MR/K026992/1
- EAEconomic and Social Research CouncilAward: ES/N000404/1
- HZHelmholtz Zentrum München
- MZMünchner Zentrum für Gesundheitswissenschaften
- NINational Institute on AgingAwards: 5R01AG042511-02, 1U34AG051425-01, N01-HC-25195, HHSN271201100004C, 1U34AG051425
- NHNational Heart, Lung, and Blood InstituteAwards: HHSN268201100007C, HHSN268201100009C, HHSN268201100011C, HHSN268201100008C, HHSN268201100006C, HHSN268201100004C, HHSN268201500001I, HHSN268201100046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C, and HHSN271201100004C, HHSN268201100005C, 5RC2HL102419, HHSN268201100010C, HHSN271201100004C, 60442456, N01-HC-25195, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100012C
- CFCenter for Information Technology
- NDNHLBI Division of Intramural Research