reviewCirculationJun 13, 2016BRONZE OA

Clinical Update: Cardiovascular Disease in Diabetes Mellitus

Joslin Diabetes Center · Meridian Clinical Research · +1 more institution

PubMed
Indexed incrossrefpubmed

Abstract

Cardiovascular disease remains the principal cause of death and disability among patients with diabetes mellitus. Diabetes mellitus exacerbates mechanisms underlying atherosclerosis and heart failure. Unfortunately, these mechanisms are not adequately modulated by therapeutic strategies focusing solely on optimal glycemic control with currently available drugs or approaches. In the setting of multifactorial risk reduction with statins and other lipid-lowering agents, antihypertensive therapies, and antihyperglycemic treatment strategies, cardiovascular complication rates are falling, yet remain higher for patients with diabetes mellitus than for those without. This review considers the mechanisms, history,…

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