Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus

Zika virus (ZIKV) is an emerging mosquito-borne flavivirus of significant public health concern. ZIKV shares a high degree of sequence and structural homology compared with other flaviviruses, including dengue virus (DENV), resulting in immunological cross-reactivity. Improving our current understanding of the extent and characteristics of this immunological cross-reactivity is important, as ZIKV is presently circulating in areas that are highly endemic for dengue. To assess the magnitude and functional quality of cross-reactive immune responses between these closely related viruses, we tested acute and convalescent sera from nine Thai patients with PCR-confirmed DENV infection against ZIKV. All of the sera…

• MU
  Mahidol University

  Award: R015636002
• NI
  National Institutes of Health

  Awards: R56AI110516, U19AI083019, 1U01AI115651, U19AI057266
• FO
  Faculty of Medicine Siriraj Hospital, Mahidol University
• NI
  National Institute of Allergy and Infectious Diseases

  Awards: U19AI057266, 1U01AI115651, 1R01AI 099385-01, U19AI083019, R56AI110516