Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction
Northwestern University · Johns Hopkins University · +5 more institutions
Abstract
Heart failure (HF) with preserved ejection fraction (EF; HFpEF) accounts for 50% of HF cases, and its prevalence relative to HF with reduced EF continues to rise. In contrast to HF with reduced EF, large trials testing neurohumoral inhibition in HFpEF failed to reach a positive outcome. This failure was recently attributed to distinct systemic and myocardial signaling in HFpEF and to diversity of HFpEF phenotypes. In this review, an HFpEF treatment strategy is proposed that addresses HFpEF-specific signaling and phenotypic diversity. In HFpEF, extracardiac comorbidities such as metabolic risk, arterial hypertension, and renal insufficiency drive left ventricular remodeling and dysfunction through systemic…
Citation impact
- FWCI
- 68.74
- Percentile
- 100%
- References
- 160
Authors
7- SJSanjiv J. ShahCorresponding
Northwestern University, Johns Hopkins University, Medical University of South Carolina, OLVG, Mayo Clinic in Arizona, Wake Forest University, Amsterdam UMC Location Vrije Universiteit Amsterdam
- DWDalane W. Kitzman
Northwestern University, Johns Hopkins University, Medical University of South Carolina, OLVG, Mayo Clinic in Arizona, Wake Forest University, Amsterdam UMC Location Vrije Universiteit Amsterdam
- BABarry A. Borlaug
Northwestern University, Johns Hopkins University, Medical University of South Carolina, OLVG, Mayo Clinic in Arizona, Wake Forest University, Amsterdam UMC Location Vrije Universiteit Amsterdam
- LVLoek van Heerebeek
Northwestern University, Johns Hopkins University, Medical University of South Carolina, OLVG, Mayo Clinic in Arizona, Wake Forest University, Amsterdam UMC Location Vrije Universiteit Amsterdam
- MRMichael R. Zile
Northwestern University, Johns Hopkins University, Medical University of South Carolina, OLVG, Mayo Clinic in Arizona, Wake Forest University, Amsterdam UMC Location Vrije Universiteit Amsterdam
Topics & keywords
- Medicine
- Heart failure with preserved ejection fraction
- Heart failure
- Cardiology
- Internal medicine
- Cyclic guanosine monophosphate
- Ejection fraction
- Pulmonary hypertension
- Good health and well-being