Transboundary and Emerging Diseases

Duck Tembusu virus (DTMUV) is an emerging avian pathogenic flavivirus that causes neurological disorders and acute egg drop syndrome in ducks. Multiple genotypes of DTMUV, including clusters 1, 2, and 3, have been identified, and recent evidence suggests a correlation between viral genotype and disease severity. Our recent study demonstrated that DTMUV cluster 2.1 induces more severe clinical disease in ducks than cluster 1; however, the underlying mechanisms responsible for this difference remain unclear. Macrophages are key target cells for DTMUV replication and play a crucial role during the early stage of viral pathogenesis. Therefore, we hypothesized that distinct DTMUV genotypes may differentially…

• CU
  Chulalongkorn University
• TS
  Thailand Science Research and Innovation
• FO
  Faculty of Veterinary Science, Chulalongkorn University