Extracellular purines, purinergic receptors and tumor growth
Indexed incrossrefpubmed
Abstract
Virtually, all tumor cells as well as all immune cells express plasma membrane receptors for extracellular nucleosides (adenosine) and nucleotides (ATP, ADP, UTP, UDP and sugar UDP). The tumor microenvironment is characterized by an unusually high concentration of ATP and adenosine. Adenosine is a major determinant of the immunosuppressive tumor milieu. Sequential hydrolysis of extracellular ATP catalyzed by CD39 and CD73 is the main pathway for the generation of adenosine in the tumor interstitium. Extracellular ATP and adenosine mold both host and tumor responses. Depending on the specific receptor activated, extracellular purines mediate immunosuppression or immunostimulation on the host side, and growth…
Citation impact
560
total citations
- FWCI
- 42.05
- Percentile
- 100%
- References
- 170
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Authors
2Topics & keywords
Keywords
- Purinergic receptor
- Adenosine
- Purinergic signalling
- Biology
- Extracellular
- Adenosine receptor
- Cell biology
- P2Y receptor
UN Sustainable Development Goals
- Good health and well-being
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