Diverse alternative back-splicing and alternative splicing landscape of circular RNAs
Chinese Academy of Sciences · Center for Excellence in Brain Science and Intelligence Technology · +4 more institutions
Abstract
Circular RNAs (circRNAs) derived from back-spliced exons have been widely identified as being co-expressed with their linear counterparts. A single gene locus can produce multiple circRNAs through alternative back-splice site selection and/or alternative splice site selection; however, a detailed map of alternative back-splicing/splicing in circRNAs is lacking. Here, with the upgraded CIRCexplorer2 pipeline, we systematically annotated different types of alternative back-splicing and alternative splicing events in circRNAs from various cell lines. Compared with their linear cognate RNAs, circRNAs exhibited distinct patterns of alternative back-splicing and alternative splicing. Alternative back-splice site…
Citation impact
- FWCI
- —
- Percentile
- —
- References
- 40
Authors
8- XZXiao‐Ou ZhangCorresponding
Chinese Academy of Sciences, Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences
- RDRui Dong
Chinese Academy of Sciences, Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences
- YZYang Zhang
Chinese Academy of Sciences, Shanghai Institutes for Biological Sciences, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences
- JZJialin Zhang
Chinese Academy of Sciences, Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences
- ZDZ. David Luo
Chinese Academy of Sciences, Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences
Topics & keywords
- Biology
- RNA splicing
- Exon
- Alternative splicing
- Intron
- Exonic splicing enhancer
- Minigene
- Genetics