Microglia development follows a stepwise program to regulate brain homeostasis

Matcovitch-Natan, Orit; Winter, Deborah R.; Giladi, Amir; Aguilar, Stephanie Vargas; Spinrad, Amit; Sarrazin, Sandrine; Ben-Yehuda, Hila; David, Eyal; González, Fabiola Zelada; Perrin, Pierre; Keren‐Shaul, Hadas; Gury, Meital; Lara-Astaiso, David; Thaiss, Christoph A.; Cohen, Merav; Halpern, Keren Bahar; Baruch, Kuti; Deczkowska, Aleksandra; Lorenzo-Vivas, Erika; Itzkovitz, Shalev; Elinav, Eran; Sieweke, Michael H.; Schwartz, Michal; Amit, Ido

doi:10.1126/science.aad8670

articleScienceJun 25, 2016Closed access

Microglia development follows a stepwise program to regulate brain homeostasis

OMOrit Matcovitch-Natan DRDeborah R. Winter AGAmir Giladi SVStephanie Vargas Aguilar ASAmit Spinrad

Weizmann Institute of Science · Centre National de la Recherche Scientifique · +3 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Microglia, the resident myeloid cells of the central nervous system, play important roles in life-long brain maintenance and in pathology. Despite their importance, their regulatory dynamics during brain development have not been fully elucidated. Using genome-wide chromatin and expression profiling coupled with single-cell transcriptomic analysis throughout development, we found that microglia undergo three temporal stages of development in synchrony with the brain--early, pre-, and adult microglia--which are under distinct regulatory circuits. Knockout of the gene encoding the adult microglia transcription factor MAFB and environmental perturbations, such as those affecting the microbiome or prenatal immune…

Citation impact

1,190

total citations

FWCI: 60.95
Percentile: 100%
References: 82

Citations per year

Authors

24

Topics & keywords

Topics

Keywords

Microglia
Epigenetics
Brain development
Biology
Neuroscience
Chromatin
Gene expression
Central nervous system

UN Sustainable Development Goals

Partnerships for the goals

No related works found for this paper.