The blood-brain barrier in Alzheimer's disease
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Abstract
Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by the pathological accumulation of amyloid beta (Aβ) peptides and neurofibrillary tangles containing hyperphosphorylated neuronal tau protein. AD pathology is also characterized by chronic brain inflammation, which promotes disease pathogenesis. In this context, the blood-brain barrier (BBB), a highly specialized endothelial cell membrane that lines cerebral microvessels, represents the interface between neural cells and circulating cells of the immune system. The BBB thus plays a key role in the generation and maintenance of chronic inflammation during AD. The BBB operates within the neurovascular unit (NVU), which includes…
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Authors
3Topics & keywords
Topics
Keywords
- Blood–brain barrier
- Neuroscience
- Disease
- Alzheimer's disease
- Medicine
- Psychology
- Pathology
- Central nervous system
UN Sustainable Development Goals
- Good health and well-being
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