Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

Bronte, Vincenzo; Brandau, Sven; Chen, Shu‐Hsia; Colombo, Mario P.; Frey, Alan B.; Greten, Tim F.; Mandruzzato, Susanna; Murray, Peter J.; Ochoa, Augusto C.; Ostrand‐Rosenberg, Suzanne; Rodrı́guez, Paulo C.; Sica, Antonio; Umansky, Viktor; Vonderheide, Robert H.; Gabrilovich, Dmitry I.

doi:10.1038/ncomms12150

reviewNature CommunicationsJul 6, 2016GOLD OA

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

VBVincenzo Bronte SBSven Brandau SCShu‐Hsia Chen MPMario P. Colombo ABAlan B. Frey

University of Verona · Essen University Hospital · +23 more institutions

PubMed

Indexed incrossrefdatacitedoajpubmed

Abstract

Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune-mediated mechanisms and those not directly associated with immune suppression. MDSC are the subject of intensive research with >500 papers published in 2015 alone. However, the phenotypic, morphological and functional heterogeneity of these cells generates confusion in investigation and analysis of their roles in inflammatory responses. The purpose of this communication is to suggest characterization standards in the burgeoning field of MDSC research.

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Topics & keywords

Topics

Keywords

Myeloid-derived Suppressor Cell
Immune system
Suppressor
Confusion
Biology
Phenotype
Immunology
Myeloid

UN Sustainable Development Goals

Good health and well-being

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