ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology
Environmental Protection Agency · Research Triangle Park Foundation · +5 more institutions
Abstract
The U.S. Environmental Protection Agency's (EPA) ToxCast program is testing a large library of Agency-relevant chemicals using in vitro high-throughput screening (HTS) approaches to support the development of improved toxicity prediction models. Launched in 2007, Phase I of the program screened 310 chemicals, mostly pesticides, across hundreds of ToxCast assay end points. In Phase II, the ToxCast library was expanded to 1878 chemicals, culminating in the public release of screening data at the end of 2013. Subsequent expansion in Phase III has resulted in more than 3800 chemicals actively undergoing ToxCast screening, 96% of which are also being screened in the multi-Agency Tox21 project. The chemical library…
Citation impact
- FWCI
- 65.60
- Percentile
- 100%
- References
- 51
Authors
18- AMAnn M. RichardCorresponding
Environmental Protection Agency, Research Triangle Park Foundation
- RJRichard Judson
Environmental Protection Agency, Research Triangle Park Foundation
- KAKeith A. Houck
Environmental Protection Agency, Research Triangle Park Foundation
- CGChris Grulke
Environmental Protection Agency, Research Triangle Park Foundation
- PVPatra Volarath
Center for Food Safety and Applied Nutrition, United States Food and Drug Administration
Topics & keywords
- Agency (philosophy)
- Biotechnology
- Computational biology
- Biology