Sex differences and hormonal effects on gut microbiota composition in mice
University of California, Los Angeles · University of Tartu · +2 more institutions
Abstract
We previously reported quantitation of gut microbiota in a panel of 89 different inbred strains of mice, and we now examine the question of sex differences in microbiota composition. When the total population of 689 mice was examined together, several taxa exhibited significant differences in abundance between sexes but a larger number of differences were observed at the single strain level, suggesting that sex differences can be obscured by host genetics and environmental factors. We also examined a subset of mice on chow and high fat diets and observed sex-by-diet interactions. We further investigated the sex differences using gonadectomized and hormone treated mice from 3 different inbred strains. Principal…
Citation impact
- FWCI
- 25.42
- Percentile
- 100%
- References
- 35
Authors
7- EOElin Org
University of California, Los Angeles, University of Tartu
- MMMargarete Mehrabian
University of California, Los Angeles
- BWBrian W. Parks
University of California, Los Angeles, University of Wisconsin–Madison
- PSPetia Shipkova
Bristol-Myers Squibb (United States)
- XLXiaoqin Liu
Bristol-Myers Squibb (United States)
Topics & keywords
- Biology
- Gut flora
- UniFrac
- Hormone
- Population
- Inbred strain
- Composition (language)
- Strain (injury)
Funding
- NINational Institutes of HealthAwards: HD07228, HL28481, T32-HD07228, HL30568, DK094311
- EREuropean Regional Development FundAwards: 2014-2020.4.01.15-0012, 2014-2020, Project No. 2014-2020.4.01.15-0012, No. 2014-2020.4.01.15-0012
- CAClinical and Translational Science Institute, University of California, Los Angeles