A Simple and Versatile Amide Directing Group for C−H Functionalizations

Achieving selective C-H activation at a single and strategic site in the presence of multiple C-H bonds can provide a powerful and generally useful retrosynthetic disconnection. In this context, a directing group serves as a compass to guide the transition metal to C-H bonds by using distance and geometry as powerful recognition parameters to distinguish between proximal and distal C-H bonds. However, the installation and removal of directing groups is a practical drawback. To improve the utility of this approach, one can seek solutions in three directions: 1) Simplifying the directing group, 2) using common functional groups or protecting groups as directing groups, and 3) attaching the directing group to…

• NS
  National Science Foundation

  Awards: CHE-0943980, CHE-0615716
• TS
  Thailand Science Research and Innovation
• NI
  National Institutes of Health

  Award: 1 R01 GM084019-01A1