A Tale of Two Sugars: Trehalose 6-Phosphate and Sucrose

Trehalose 6-phosphate (Tre6P), the intermediate of trehalose biosynthesis, is an essential signal metabolite in plants, linking growth and development to carbon status. The Suc-Tre6P nexus model postulates that Tre6P is both a signal and negative feedback regulator of Suc levels, forming part of a mechanism to maintain Suc levels within an optimal range and functionally comparable to the insulin-glucagon system for regulating blood Glc levels in animals. The target range and sensitivity of the Tre6P-Suc feedback control circuit can be adjusted according to the cell type, developmental stage, and environmental conditions. In source leaves, Tre6P modulates Suc levels by affecting Suc synthesis, whereas in sink…

• CN
  Consejo Nacional de Investigaciones Científicas y Técnicas
• M
  Max-Planck-Gesellschaft
• AN
  Agencia Nacional de Promoción Científica y Tecnológica