The Safety, Tolerability and Risks Associated with the Use of Newer Generation Antidepressant Drugs: A Critical Review of the Literature
Universidade Federal do Ceará · The University of Texas Health Science Center at Houston · +4 more institutions
Abstract
Newer generation antidepressant drugs (ADs) are widely used as the first line of treatment for major depressive disorders and are considered to be safer than tricyclic agents. In this critical review, we evaluated the literature on adverse events, tolerability and safety of selective serotonin reuptake inhibitors, serotonin noradrenaline reuptake inhibitors, bupropion, mirtazapine, trazodone, agomelatine, vilazodone, levomilnacipran and vortioxetine. Several side effects are transient and may disappear after a few weeks following treatment initiation, but potentially serious adverse events may persist or ensue later. They encompass gastrointestinal symptoms (nausea, diarrhea, gastric bleeding, dyspepsia),…
Citation impact
- FWCI
- 45.01
- Percentile
- 100%
- References
- 251
Authors
5- AFAndré F. CarvalhoCorresponding
Universidade Federal do Ceará
- MSManu Sharma
The University of Texas Health Science Center at Houston
- ARAndré R. Brunoni
Universidade de São Paulo
- EVEduard Vieta
Centro de Investigación Biomédica en Red de Salud Mental, Universitat de Barcelona
- GAGiovanni A. Fava
University at Buffalo, State University of New York
Topics & keywords
- Medicine
- Adverse effect
- Trazodone
- Tolerability
- Mirtazapine
- Venlafaxine
- Nefazodone
- Discontinuation
- Good health and well-being