Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

Registry, PARALS; Rheenen, Wouter van; Group, SLALOM; Registry, SLAP; Group, NNIPPS Study; Shatunov, Aleksey; Dekker, Annelot M.; McLaughlin, Russell L.; Diekstra, Frank P.; Pulit, Sara L.; Spek, Rick A. A. van der; Võsa, Urmo; Jong, Simone de; Robinson, Matthew R.; Yang, Jian; Fogh, Isabella; Doormaal, Perry Tc van; Tazelaar, Gijs; Koppers, Max; Blokhuis, Anna M.; Sproviero, William; Jones, Ashley R; Kenna, Kevin P.; Eijk, Kristel R. van; Harschnitz, Oliver; Schellevis, Raymond D.; Brands, William J.; Medic, Jelena; Menelaou, Androniki; Vajda, Alice; Ticozzi, Nicola; Lin, Kuang; Rogelj, Boris; Vrabec, Katarina; Ravnik‐Glavač, Metka; Koritnik, Blaž; Zidar, Janez; Leonardis, Lea; Grošelj, Leja Dolenc; Millecamps, Stéphanie; Salachas, François; Meininger, Vincent; Carvalho, Mamede de; Pinto, Susana; Mora, Jesús S.; Rojas-García, Ricardo; Polak, Meraida; Chandran, Siddharthan; Colville, Shuna; Swingler, Robert; Morrison, Karen; Shaw, Pamela J.; Hardy, John; Orrell, Richard W.; Pittman, Alan; Sidle, Katie; Fratta, Pietro; Malaspina, Andrea; Topp, Simon; Petri, Susanne; Abdulla, Susanne; Drepper, Carsten; Sendtner, Michael; Meyer, Thomas; Ophoff, Roel A.; Staats, Kim A.; Wiedau‐Pazos, Martina; Lomen‐Hoerth, Catherine; Deerlin, Vivianna M. Van; Trojanowski, John Q.; Elman, Lauren; McCluskey, Leo; Başak, A. Nazlı; Tunca, Ceren; Hamzeiy, Hamid; Parman, Yeşim; Meitinger, Thomas; Lichtner, Peter; Radivojkov‐Blagojevic, Milena; Andrés, Christian; Maurel, Cindy; Bensimon, Gilbert; Landwehrmeyer, G. Bernhard; Brice, Alexis; Payan, Christine; Saker-Delye, Safaa; Dürr, Alexandra; Wood, Nicholas; Tittmann, Lukas; Lieb, Wolfgang; Franke, André; Rietschel, Marcella; Cichon, Sven; Nöthen, Markus M.; Amouyel, Philippe; Tzourio, Christophe; Dartigues, Jean‐François; Uitterlinden, André G.; Rivadeneira, Fernando; Estrada, Karol; Hofman, Albert; Curtis, Charles; Blauw, Hylke M.; Kooi, Anneke J. van der; Visser, Marianne de; Goris, An; Weber, Markus; Shaw, Christopher E.; Smith, Bradley; Pansarasa, Orietta; Cereda, Cristina; Bo, Roberto Del; Comi, Giacomo P.; D’Alfonso, Sandra; Bertolin, Cinzia; Sorarú, Gianni; Mazzini, Letizia; Pensato, Viviana; Gellera, Cinzia; Tiloca, Cinzia; Ratti, Antonia; Calvo, Andrea; Moglia, Cristina; Brunetti, Maura; Arcuti, Simona; Capozzo, Rosa; Zecca, Chiara; Lunetta, Christian; Penco, Silvana; Riva, Nilo; Padovani, Alessandro; Filosto, Massimiliano; Müller, Bernard; Stuit, Robbert Jan; Blair, Ian P.; Zhang, Katharine; McCann, Emily P.; Fifita, Jennifer A.; Nicholson, Garth A.; Rowe, Dominic B.; Pamphlett, Roger; Kiernan, Matthew C.; Großkreutz, Julian; Witte, Otto W.; Ringer, Thomas; Prell, Tino; Stubendorff, Beatrice; Kurth, Ingo; Hübner, Christian A.; Leigh, P. Nigel; Casale, Federico; Chiò, Adriano; Beghi, Ettore; Pupillo, Elisabetta; Tortelli, Rosanna; Logroscino, Giancarlo; Powell, John; Ludolph, Albert C.; Weishaupt, Jochen H.; Robberecht, Wim; Damme, Philip Van; Franke, Lude; Pers, Tune H.; Brown, Robert H.; Glass, Jonathan D.; Landers, John E.; Hardiman, Orla; Andersen, Peter M.; Corcia, Philippe; Vourc’h, Patrick; Silani, Vincenzo; Wray, Naomi R.; Visscher, Peter M.; Bakker, Paul I. W. de; Es, Michael A. van; Pasterkamp, R. Jeroen; Lewis, Cathryn M.; Breen, Gerome; Al‐Chalabi, Ammar; Berg, Leonard H. van den; Veldink, Jan H.

doi:10.1038/ng.3622

articleNature GeneticsJul 25, 2016BRONZE OA

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

PRPARALS RegistryWVWouter van RheenenSGSLALOM GroupSRSLAP RegistryNSNNIPPS Study Group

University Medical Center Utrecht · King's College London · +103 more institutions

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PR
PARALS RegistryCorresponding
University Medical Center Utrecht
WV
Wouter van Rheenen
King's College London, University Medical Center Utrecht
SG
SLALOM Group
University Medical Center Utrecht
SR
SLAP Registry
Trinity College Dublin
NS
NNIPPS Study Group
University Medical Center Utrecht

Topics & keywords

Topics

Keywords

Genetic architecture
Genome-wide association study
Amyotrophic lateral sclerosis
Biology
Imputation (statistics)
Genetics
Genetic association
Heritability

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