Liposomes Coated with Isolated Macrophage Membrane Can Target Lung Metastasis of Breast Cancer
Chinese Academy of Sciences · Shanghai Institute of Materia Medica · +1 more institution
Abstract
Cancer metastasis leads to high mortality of breast cancer and is difficult to treat because of the poor delivery efficiency of drugs. Herein, we report the wrapping of a drug-carrying liposome with an isolated macrophage membrane to improve delivery to metastatic sites. The macrophage membrane decoration increased cellular uptake of the emtansine liposome in metastatic 4T1 breast cancer cells and had inhibitory effects on cell viability. In vivo, the macrophage membrane enabled the liposome to target metastatic cells and produced a notable inhibitory effect on lung metastasis of breast cancer. Our results provide a biomimetic strategy via the biological properties of macrophages to enhance the medical…
Citation impact
- FWCI
- 19.25
- Percentile
- 100%
- References
- 40
Authors
7- HCHaiqiang CaoCorresponding
Chinese Academy of Sciences, Shanghai Institute of Materia Medica, University of Chinese Academy of Sciences
- ZDZhaoling Dan
Chinese Academy of Sciences, Shanghai Institute of Materia Medica
- XHXinyu He
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, University of Chinese Academy of Sciences
- ZZZhiwen Zhang
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- HYHaijun Yu
Chinese Academy of Sciences, Shanghai Institute of Materia Medica
Topics & keywords
- Liposome
- Metastasis
- Metastatic breast cancer
- Macrophage
- In vivo
- Cancer
- Cancer research
- Breast cancer
- Good health and well-being