Synthetic Applications of Proton-Coupled Electron Transfer

Redox events in which an electron and proton are exchanged in a concerted elementary step are commonly referred to as proton-coupled electron transfers (PCETs). PCETs are known to operate in numerous important biological redox processes, as well as recent inorganic technologies for small molecule activation. These studies suggest that PCET catalysis might also function as a general mode of substrate activation in organic synthesis. Over the past three years, our group has worked to advance this hypothesis and to demonstrate the synthetic utility of PCET through the development of novel catalytic radical chemistries. The central aim of these efforts has been to demonstrate the ability of PCET to homolytically…

• AP
  Alfred P. Sloan Foundation
• PU
  Princeton University
• AC
  American Chemical Society Petroleum Research Fund
• NI
  National Institute of General Medical Sciences

  Award: R01 GM113105