Human Coronaviruses: A Review of Virus–Host Interactions

Human coronaviruses (HCoVs) are known respiratory pathogens associated with a range of respiratory outcomes. In the past 14 years, the onset of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) have thrust HCoVs into spotlight of the research community due to their high pathogenicity in humans. The study of HCoV-host interactions has contributed extensively to our understanding of HCoV pathogenesis. In this review, we discuss some of the recent findings of host cell factors that might be exploited by HCoVs to facilitate their own replication cycle. We also discuss various cellular processes, such as apoptosis, innate immunity, ER stress…

• NR
  National Research Foundation

  Award: CRP8-2011-05
• NR
  National Research Foundation Singapore

  Awards: RGT17/13, CRP8-2011-05, NRF-CRP8-2011-05
• MO
  Ministry of Education - Singapore

  Awards: Tier 1, AcRF Tier 2, Tier 2 grant (ACR47/14), ACR47/14, Tier 2
• NT
  Nanyang Technological University

  Award: Tier 1