Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes Mellitus
Mount Sinai Hospital · St. Michael's Hospital · +5 more institutions
Abstract
Sodium-glucose cotransporter-2 (SGLT2) inhibitors, including empagliflozin, dapagliflozin, and canagliflozin, are now widely approved antihyperglycemic therapies. Because of their unique glycosuric mechanism, SGLT2 inhibitors also reduce weight. Perhaps more important are the osmotic diuretic and natriuretic effects contributing to plasma volume contraction, and decreases in systolic and diastolic blood pressures by 4 to 6 and 1 to 2 mm Hg, respectively, which may underlie cardiovascular and kidney benefits. SGLT2 inhibition also is associated with an acute, dose-dependent reduction in estimated glomerular filtration rate by ≈5 mL·min(-1)·1.73 m(-2) and ≈30% to 40% reduction in albuminuria. These effects…
Citation impact
- FWCI
- 84.28
- Percentile
- 100%
- References
- 145
Authors
5- HJHiddo J.L. HeerspinkCorresponding
Mount Sinai Hospital, St. Michael's Hospital, University Medical Center Groningen, University of Groningen, University of Toronto, Toronto General Hospital, Diabetes Canada
- BABruce A. Perkins
Mount Sinai Hospital, St. Michael's Hospital, University Medical Center Groningen, University of Groningen, University of Toronto, Toronto General Hospital, Diabetes Canada
- DFDavid Fitchett
Mount Sinai Hospital, St. Michael's Hospital, University Medical Center Groningen, University of Groningen, University of Toronto, Toronto General Hospital, Diabetes Canada
- MHMansoor Husain
Mount Sinai Hospital, St. Michael's Hospital, University Medical Center Groningen, University of Groningen, University of Toronto, Toronto General Hospital, Diabetes Canada
- DZDavid Z.I. Cherney
Mount Sinai Hospital, St. Michael's Hospital, University Medical Center Groningen, University of Groningen, University of Toronto, Toronto General Hospital, Diabetes Canada
Topics & keywords
- Empagliflozin
- Medicine
- Internal medicine
- Renal function
- Diabetes mellitus
- Tubuloglomerular feedback
- Endocrinology
- Kidney disease
- Good health and well-being