Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans
Western University · Radboud University Nijmegen · +6 more institutions
Abstract
Elevated lipoprotein(a) [Lp(a)] is a prevalent, independent cardiovascular risk factor, but the underlying mechanisms responsible for its pathogenicity are poorly defined. Because Lp(a) is the prominent carrier of proinflammatory oxidized phospholipids (OxPLs), part of its atherothrombosis might be mediated through this pathway.
In vivo imaging techniques including magnetic resonance imaging, (18)F-fluorodeoxyglucose uptake positron emission tomography/computed tomography and single-photon emission computed tomography/computed tomography were used to measure subsequently atherosclerotic burden, arterial wall inflammation, and monocyte trafficking to the arterial wall. Ex vivo analysis of monocytes was performed with fluorescence-activated cell sorter analysis, inflammatory stimulation assays, and transendothelial migration assays. In vitro studies of the pathophysiology of Lp(a) on monocytes were performed with an in vitro model for trained immunity.
Citation impact
- FWCI
- 18.22
- Percentile
- 100%
- References
- 53
Authors
18- FMFleur M. van der ValkCorresponding
Western University, Radboud University Nijmegen, St. Boniface Hospital, Radboud University Medical Center, University of California San Diego, University of Manitoba, University of Windsor, Amsterdam UMC Location Vrije Universiteit Amsterdam
- SBSiroon Bekkering
Western University, Radboud University Nijmegen, St. Boniface Hospital, Radboud University Medical Center, University of California San Diego, University of Manitoba, University of Windsor, Amsterdam UMC Location Vrije Universiteit Amsterdam
- JKJeffrey Kroon
Western University, Radboud University Nijmegen, St. Boniface Hospital, Radboud University Medical Center, University of California San Diego, University of Manitoba, University of Windsor, Amsterdam UMC Location Vrije Universiteit Amsterdam
- CYCalvin Yeang
Western University, Radboud University Nijmegen, St. Boniface Hospital, Radboud University Medical Center, University of California San Diego, University of Manitoba, University of Windsor, Amsterdam UMC Location Vrije Universiteit Amsterdam
- JVJan Van den Bossche
Western University, Radboud University Nijmegen, St. Boniface Hospital, Radboud University Medical Center, University of California San Diego, University of Manitoba, University of Windsor, Amsterdam UMC Location Vrije Universiteit Amsterdam
Topics & keywords
- Proinflammatory cytokine
- Inflammation
- Medicine
- Monocyte
- In vivo
- Lipoprotein
- Ex vivo
- Immunology