Identification of a novel plasmid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Belgium, June 2016
University of Antwerp · Ross University School of Veterinary Medicine · +2 more institutions
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Abstract
We identified a novel plasmid-mediated colistin-resistance gene in porcine and bovine colistin-resistant Escherichia coli that did not contain mcr-1. The gene, termed mcr-2, a 1,617 bp phosphoethanolamine transferase harboured on an IncX4 plasmid, has 76.7% nucleotide identity to mcr-1. Prevalence of mcr-2 in porcine colistin-resistant E. coli (11/53) in Belgium was higher than that of mcr-1 (7/53). These data call for an immediate introduction of mcr-2 screening in ongoing molecular epidemiological surveillance of colistin-resistant Gram-negative pathogens.
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770
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Authors
7Topics & keywords
Topics
Keywords
- MCR-1
- Colistin
- Plasmid
- Escherichia coli
- Microbiology
- Biology
- Gene
- Enterobacteriaceae
UN Sustainable Development Goals
- Good health and well-being
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