Specification of tissue-resident macrophages during organogenesis

Mass, Elvira; Ballesteros, Iván; Farlik, Matthias; Halbritter, Florian; Günther, Patrick; Crozet, Lucile; Jacome-Galarza, Christian E.; Händler, Kristian; Klughammer, Johanna; Kobayashi, Yasuhiro; Perdiguero, Elisa Gomez; Schultze, Joachim L.; Beyer, Marc; Bock, Christoph; Geissmann, Frédéric

doi:10.1126/science.aaf4238

articleScienceAug 4, 2016GREEN OA

Specification of tissue-resident macrophages during organogenesis

EMElvira Mass IBIván Ballesteros MFMatthias Farlik FHFlorian Halbritter PGPatrick Günther

Memorial Sloan Kettering Cancer Center · Austrian Academy of Sciences · +8 more institutions

PubMed

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Abstract

INTRODUCTION Embryonic development and tissue homeostasis depend on cooperation between specialized cell types. Resident macrophages are professional phagocytes that survey their surroundings; eliminate unfit cells, microorganisms, and metabolic waste; and produce a large range of bioactive molecules and growth factors. Resident macrophages also serve tissue-specific purposes: For example, microglia in the central nervous system support neuronal circuit development, Kupffer cells scavenge blood particles and dying red blood cells in the liver, and alveolar macrophages uptake surfactant and remove airborne pollutants and microbes from the airways. Resident macrophage diversity in adult mice is reflected in…

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Keywords

Organogenesis
Cell biology
Biology
Computational biology
Computer science
Biochemistry

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