LC3/GABARAP family proteins: autophagy‐(un)related functions
Maastricht University · Maastro Clinic
Abstract
From yeast to mammals, autophagy is an important mechanism for sustaining cellular homeostasis through facilitating the degradation and recycling of aged and cytotoxic components. During autophagy, cargo is captured in double-membraned vesicles, the autophagosomes, and degraded through lysosomal fusion. In yeast, autophagy initiation, cargo recognition, cargo engulfment, and vesicle closure is Atg8 dependent. In higher eukaryotes, Atg8 has evolved into the LC3/GABARAP protein family, consisting of 7 family proteins [LC3A (2 splice variants), LC3B, LC3C, GABARAP, GABARAPL1, and GABARAPL2]. LC3B, the most studied family protein, is associated with autophagosome development and maturation and is used to monitor…
Citation impact
- FWCI
- 31.48
- Percentile
- 100%
- References
- 128
Authors
4Topics & keywords
- ATG8
- Autophagy
- Cell biology
- Protein family
- Autophagosome
- ULK1
- Chemistry
- Biology